TABLE 4.
Bactericidal activity against serotype C M. catarrhalis with mouse and rabbit antisera elicited by conjugates
| Immunogena | Geometric mean mouse bactericidal titer (range)b | Geometric mean rabbit bactericidal titer (rabbit 1 value; rabbit 2 value)b |
|---|---|---|
| dLOS-TT | 13 (9-18) | <5 |
| dLOS-CRM-1 | 14 (10-20) | <5 |
| dLOS-CRM-2 | 23 (17-32) | <5 |
| dLOS-TT, Ribi | 23 (14-37)c | 37 (20; 80) |
| dLOS-CRM-1, Ribi | 29 (16-56)d | 40 (40; 40) |
| dLOS-CRM-2, Ribi | 51 (36-73)d | 28 (20; 40) |
| dLOS, TT, CRM, Ribi | <5 | <5 |
a
See Table 2, footnote a, for mice and Table 3, footnote a, for rabbits. Test antisera were collected after three injections.
b
The reciprocal of the highest serum dilution causing >50% killing was expressed as the bactericidal titer.
c
P < 0.05 for a comparison with the corresponding group without Ribi adjuvant.
d
P < 0.01 for a comparison with the corresponding group without Ribi adjuvant.