TABLE 3.

Degree of inflammation and C. burnetii antigen distribution in mice infected with the high dose of NM I or NM II at 28 DPI

Mice	Mean inflammation score (mean antigen distribution score) witha:
	NM I infection				NM II infection				PBS (heart, lung, liver, and spleen)
	Heart	Lung	Liver	Spleen	Heart	Lung	Liver	Spleen
SCIDbg					0.0 (0.0)	0.0 (0.0)	2.8b (1.0b)	0.0 (2.0b)	0.0 (0.0)
SCID					0.0 (0.0)	0.0 (0.0)	2.0b (0.8b)	1.0b (2.0b)	0.0 (0.0)
wt (CB17)					0.0 (0.0)	0.3 (0.0)	0.8 (0.0)	0.0 (0.0)	0.0 (0.0)
Nude	0.0 (1.5b)	0.0 (1.9b)	1.5 (3.5b)	0.0b (4.0)b	0.0 (0.0)	1.0b (0.0)	1.0 (0.3)	1.0b (0.7)	0.0 (0.0)
muMT	1.3 (0.0)	1.3b (0.0)	3.0b (0.0)	3.3b (0.0)	0.1 (0.0)	0.3 (0.0)	2.3b (0.0)	0.0 (0.0)	0.0 (0.0)
bg	0.9 (0.0)	0.1 (0.0)	2.8b (0.0)	3.0 (1.7)	0.0 (0.0)	0.1 (0.0)	1.0 (0.0)	0.0 (0.0)	0.0 (0.0)
TNF-α−/−	3.2b (1.3b)	0.0 (0.0)	2.7 (3.0b)	1.7 (2.0b)	0.0 (0.0)	0.1 (0.0)	1.0 (0.0)	0.0 (0.5)	0.0 (0.0)
IFN-γ−/−	1.5b (1.3b)	1.1b (1.8b)	3.3b (3.5b)	2.3 (2.0)	0.0 (0.0)	0.1 (0.0)	0.0b (0.0)	0.0 (0.0)	0.0 (0.0)
wt (B6)	0.4 (0.0)	0.1 (0.0)	2.0 (1.0)	2.3 (1.0)	0.3 (0.0)	0.0 (0.0)	1.0 (0.0)	0.0 (0.0)	0.0 (0.0)

^a0, none; 1, mild; 2, moderate; 3, marked; 4, severe. High-dose NM I infection of SCIDbg, SCID, and wt (CB17) mice was not performed.

^bP < 0.05 for a comparison with the wt group with the same infection.