TABLE 1.
Blood culture results after challenge of rabbits with B. anthracis Ames spores by nasal instillationa
| Time of sacrifice postinfection (h) | PBS control rabbitsb
|
AVP-21D9 (2 mg/kg)-immunized rabbitsc
|
||||
|---|---|---|---|---|---|---|
| Temp (°C)d | No. with positive blood culture (no. dead)/total | No. phage susceptible/ total | Temp (°C)e | No. with positive blood culture/total | No. phage susceptible/ total | |
| 0 (uninfected) | ||||||
| 12 | 39.5 | 1/3 | 0/1 | 39.9 | 1/3 | 0/1 |
| 24 | 39.6 | 1/3 | 1/1 | 40.9 | 0/3 | 0/0 |
| 36 | 41.0 | 3/3 | 3/3 | 40.1 | 0/3 | 0/0 |
| 48 | 39.4 | 1/3 | 1/1 | 39.5 | 0/3 | 0/0 |
| 60 | 39.2 | 3 (2)/5 | 3/3 | 39.0 | 1/3 | 1/1 |
| 72 | 1 (1)/1 | 1/1 | 38.5 | 0/3 | 0/0 | |
a
AVP-21D9 was given by the s.c. route at the time of spore challenge; n = 3 rabbits/group. Blood samples were cultured by enrichment for up to 14 days in Luria-Bertani broth prior to streaking onto 5% sheep blood agar. Confirmation of B. anthracis was by typing with γ phage.
b
Rabbits infected with B. anthracis but unimmunized.
c
Rabbits infected with B. anthracis and immunized.
d
Average temperature, 39.7 ± 0.6°C.
e
Average temperature, 39.7 ± 0.7°C.