TABLE 4.
Rabbit-specific anti-PA ELISA titers of rabbits dosed with AVP-21D9 human anti-PA MAb
| Rabbit strain and challenge routea | Rabbit-specific anti-PA titer (reciprocal dilution)b at:
|
||
|---|---|---|---|
| 1 wk after primary spore challenge | 5 wk after primary spore challenge | 7 wk after primary spore challenge and 2 wk after secondary spore challenge | |
| DB | |||
| Aerosol | 1,158 ± 781 | 375 ± 122 | 1,644 ± 1,165 |
| Intranasal | 400 ± 100 | 454 ± 120 | 192 ± 132 |
| NZ | |||
| Aerosol | 583 ± 461 | 279 ± 55 | 244 ± 138 |
| Intranasal | 342 ± 51 | 345 ± 60 | 223 ± 158 |
a
DB, Dutch-belted dwarf rabbits; NZ, New Zealand White rabbits.
b
Mean (± standard deviation) reciprocal dilution yielding 50% of the maximum reading at 405 nm. There were six rabbits in each group.