TABLE 1.
Summary of anidulafungin MIC and MEC ranges and interlaboratory agreement at two incubation times in seven of eight laboratories
| Species and isolate | MIC or MEC, μg/ml (% interlaboratory agreement)
|
|||
|---|---|---|---|---|
| 24 h
|
48 h
|
|||
| MICb | MEC | MICb | MEC | |
| A. fumigatus | ||||
| ATCC MYA-3626 | <0.015 (75) | <0.015 (100) | <0.015 (63) | <0.015 (100) |
| ATCC MYA-3627 | <0.015 (75) | <0.015 (100) | <0.015 (62) | <0.015 (100) |
| A. flavus ATCC MYA-3631 | <0.015 (75) | <0.015 (100) | <0.015 (54) | <0.015 (91.7) |
| A. terreus | ||||
| ATCC MYA-3628 | <0.015 (63) | <0.015 (100) | <0.015 (49) | <0.015 (75) |
| ATCC MYA-3633 | <0.015 (63) | <0.015 (99.6) | <0.015 (54) | <0.015 (99.6) |
| A. nidulans ATCC MYA-3632 | <0.015 (75) | <0.015 (100) | <0.015 (67) | <0.015 (96.7) |
| F. solani ATCC MYA-3636 | >32 (87) | >32 (59) | >32 (96.7) | >32 (87) |
| F. moniliforme ATCC MYA-3629 | >32 (94.2) | >32 (82.5) | >32 (97.5) | >32 (87.5) |
| S. apiospermuma | ||||
| ATCC MYA-3634 | 1-4 (59) | 1-4 (90) | 1-4 (50) | 1-4 (96.7) |
| ATCC MYA-3635 | 1-4 (47) | 1-4 (79) | 1-4 (46) | 1-4 (94) |
| P. variotii ATCC MYA-3630 | <0.015 (75) | <0.015 (100) | <0.015 (75) | <0.015 (100) |
a
For S. apiospermum, incubation was for 48 and 72 h.
b
≥50% growth inhibition MICs.