TABLE 1.
Concordance between HC2, AMP, and LA HPV tests in detecting HR-HPV genotypes among 1,676 PreservCyt specimens
| Test resulta | No. of specimens (%) with AMP HPV test resultb
|
Total no. of specimens (%) | ||
|---|---|---|---|---|
| Positive | Negative | |||
| HC2 result | ||||
| Positive | 1,020 | 52 | 1,072 (64.0) | |
| Negative | 209 | 395 | 604 (36.0) | |
| Total | 1,229 (73.3) | 447 (26.7) | 1,676 | |
| No. of specimens (%) with LA-HPV test resultc
|
||||
| Positive
|
Negative
|
|||
| HC2 result | ||||
| Positive | 1,010 | 62 | 1,072 (64.0) | |
| Negative | 206 | 398 | 604 (36.0) | |
| Total | 1,216 (72.6) | 460 (27.4) | 1,676 | |
| No. of specimens (%) with LA-HPV test resultd
|
||||
| Positive
|
Negative
|
|||
| AMP result | ||||
| Positive | 1,204 | 25 | 1,229 (73.3) | |
| Negative | 12 | 435 | 447 (26.7) | |
| Total | 1,216 (72.6) | 460 (27.4) | 1,676 | |
a
A positive result refers to HR-HPV detection; a negative result reflects the absence of HR-HPV.
b
Absolute agreement = 84.4%, κ = 0.6419 (95% confidence interval [CI] = 0.6032 to 0.6806; P < 0.0001). Agreement between tests was assessed by Cohen's kappa statistic. P values were calculated by using McNemar's test.
c
Absolute agreement = 84.0%, κ = 0.6341 (95% CI = 0.5950 to 0.6732; P < 0.0001).
d
Absolute agreement = 97.8%, κ = 0.9441 (95% CI = 0.9263 to 0.9619; P = 0.0485).