TABLE 4.
Relationship between histological diagnosis and HR-HPV testing
| HR-HPV resulta | Histology diagnosis (no. of specimens)b
|
Sensitivity or specificity (95% CI) | Positive or negative predictive values (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Normal | CIN1 | CIN2 | CIN3 | ACISc | SCCd | ≥CIN2 | NAe | |||
| HC2+ | 59 | 103 | 147 | 260 | 5 | 9 | 421 | 489 | 79.0 (76.3-81.7) | 72.2 (69.3-75.1) |
| HC2− | 111 | 93 | 57 | 51 | 4f | 0 | 112 | 288 | 55.7 (52.5-59.0) | 64.6 (61.4-67.7) |
| AMP+ | 66 | 118 | 176 | 295 | 9 | 9 | 489 | 556 | 91.7 (89.9-93.5) | 72.7 (69.3-75.1) |
| AMP− | 104 | 78 | 28 | 16 | 0 | 0 | 44 | 221 | 49.7 (46.5-53.0) | 80.5 (77.9-83.1) |
| P (HC2 vs AMP) | 0.4998 | 0.1538 | 0.0006 | <0.0001 | 0.0824 | 1.0 | <0.0001 | |||
| LA+ | 66 | 114 | 176 | 291 | 9 | 9 | 485 | 551 | 91.0 (89.1-92.9) | 72.9 (70.0-75.8) |
| LA− | 104 | 82 | 28 | 20 | 0 | 0 | 48 | 226 | 50.8 (47.6-54.1) | 79.5 (76.8-82.1) |
| P (HC2 vs LA) | 0.4998 | 0.3096 | 0.0006 | <0.0001 | 0.0824 | 1.0 | <0.0001 | |||
| Total | 170 | 196 | 204 | 311 | 9 | 9 | 533 | 777 | ||
a
An LA+ result refers to the detection of a HR-HPV genotype; likewise, an LA− result refers to the absence of an HR-HPV genotype.
b
P values, derived as indicated in column 1, were calculated by using the Fisher exact test.
c
This specimen was also diagnosed as ACIS by histology.
d
SCC, squamous cell carcinoma.
e
NA, not available.
f
Four HC2-negative specimens were from women with ACIS (by histology).