TABLE 3.
Helicobacter species isolated from commercial and research mouse colonies in the United Statesa
| Source | No. mice tested/no. of Helicobacter spp. culture positive | WT/GEM: genotype (background) | Age or characteristic | Helicobacter species identified | No. of isolates identified by:
|
|
|---|---|---|---|---|---|---|
| PCR | Sequencing | |||||
| Commercial | ||||||
| Company 1 | 4/0 | WT (AJ) | Various | Negative | NA | |
| Company 2 | 2/2 | WT (BALB/c) | Retired breeders | H. hepaticus, H. bilis, and H. rodentium | 6 | |
| Company 2 | 2/2 | WT (AJ) | Retired breeders | H. hepaticus, H. bilis, and H. rodentium | 6 | |
| Company 2 | 2/0 | WT (AJ) | Retired breeders | Negative | NA | |
| Research institutions | ||||||
| Institution 1 (California) | 1/1 | GEM: HIF 1A (129) | 7 mo+ | H. hepaticus | 1 | |
| Institution 2 (California) | 1/1 | GEM: HYPOE (C57BL/6) | 11 mo+ | H. hepaticus | 1 | |
| Institution 3 (Maryland) | 2/0 | GEM: c-myc (C57BL/6/CBA/J) | 11 mo+ | Negative | NA | |
| Institution 4 (Massachusetts) | 2/2 | GEM: Smo−/− (C57BL/6) | 7 mo | H. hepaticus | 2 | |
| Institution 4 (Massachusetts) | 2/2 | GEM: ICOS KO (129) | 15 wk | H. bilis | 2 | |
| Institution 5 (Massachusetts) | 2/2 | GEM: Fibrogen−/−; VWF−/− | 11 mo | H. hepaticus | 2 | |
| Institution 6 (Massachusetts) | 2/2 | WT (C57BL/6) | 7 mo+ | H. hepaticus | 2 | |
| Institution 7 (Massachusetts) | 2/2 | GEM: CARR | 8 mo+ | H. hepaticus | 2 | |
| Institution 8 (Massachusetts) | 2/2 | GEM: TLR2 (C57BL/6) | 9 wk | H. mastomyrinus | 1 | |
| Institution 8 (Massachusetts) | 2/2 | WT (B6/129) | 6 wk | H. mastomyrinus | 1 | |
| Institution 8 (Massachusetts) | 1/1 | GEM: INS-GASGgly (FVB) | H rodentium | 1 | ||
| Institution 8 (Massachusetts) | 1/0 | GEM: TFF2 (C57BL/6) | 7 mo+ | Negative | NA | |
| Institution 8 (Massachusetts) | 1/0 | GEM: INS-GAS (C57BL/6) | Negative | NA | ||
| Institution 9 (New York) | 1/1 | GEM: DYT (C57BL/6) | 9 mo+ | Helicobacter sp. MIT 96-1001 | 1 | |
| Institution 9 (New York) | 1/1 | GEM: DYT (C57BL/6) | 9 mo+ | H. hepaticus and H. typhlonius | 2 | |
| Institution 10 (New York) | 2/2 | WT (FVB) | 11 mo+ | H. hepaticus and H. typhlonius | 4 | |
| Institution 11 (New York) | 1/1 | GEM: E2F1+/− | 7 mo+ | H. hepaticus and H. typhlonius | 2 | |
| Institution 12 (Ohio) | 2/2 | GEM (C57BL/6-AJ) | 8 mo+ | H. hepaticus | 2 | |
| Institution 13 (Ohio) | 2/2 | GEM: Pdx-cre | 12 mo+ | H. hepaticus and H. typhlonius | 4 | |
| Institution 14 (Tennessee) | 2/2 | GEM: p48-cre | 10 mo+ | H. hepaticus and H. typhlonius | 4 | |
| Institution 15 (Texas) | 1/1 | GEM: mdm2 (129) | 7 mo+ | H. hepaticus and H. typhlonius | 2 | |
| Institution16 (Texas) | 1/1 | GEM: 2-MHCGSK-3BS9A | 12 mo+ | H. hepaticus and H. typhlonius | 2 | 1 |
| Total | 44/34 | 47 | 4 | |||
a
WT, wild type; GEM, genetically engineered mice; NA, not applicable.