TABLE 2.
Overall sensitivity and specificity results for HIV DNA assay and Up24 antigen assay for infants 0 to 180 days old and 8 to 180 days old compared with final infection status
| Subject age (days) | Result (95% confidence interval)a
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Up24 with kit buffer
|
HIV DNA assay
|
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| Sensitivity | Specificity | PPV | NPV | Sensitivity | Specificity | PPV | NPV | |
| 0-180 | 0.917 (0.852-0.955) | 0.985 (0.971-0.992) | 0.940 (0.891-0.968) | 0.975 (0.951-0.987) | 0.883 (0.821-0.926) | 0.994 (0.984-0.998) | 0.977 (0.931-0.993) | 0.970 (0.950-0.982) |
| 8-180 | 0.937 (0.876-0.970) | 0.983 (0.968-0.991) | 0.946 (0.898-0.972) | 0.979 (0.955-0.990) | 0.900 (0.842-0.938) | 0.993 (0.979-0.998) | 0.977 (0.930-0.993) | 0.969 (0.948-0.981) |
a
Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were all estimated from a repeated-measures model with GEE. The numbers of samples tested are as follows: Up24 with subjects of 0 to 180 days old, 802; Up24 with subjects of 8 to 180 days old, 688; HIV DNA assay with subjects of 0 to 180 days old, 691; HIV DNA assay with subjects of 8 to 180 days old, 577.