TABLE 4.

Correlation between inhibition zone diameters (in millimeters) obtained by the disk diffusion method and reference M38-A MICs (amphotericin B and triazoles) and MECs (caspofungin) for 483 mold isolates at three of the five centers^a

Antifungal agent and incubation time (h)b	Correlation coefficient (R value)c for:
	MH	MGM
Itra
24	0.79	ND
48	0.75	0.58
72	0.74	0.67
Posa
24	0.77	ND
48	0.71	0.65
72	0.71	0.71
Vori-1
24	0.85	ND
48	0.83	0.87
72	0.82	0.53
Vori-10
24	0.83	ND
48	0.80	0.85
72	0.83	0.58
Cas-BBL
24	0.92	ND
48	0.88	0.96
72	0.90	0.87
Cas-Oxoid
24	0.93	ND
48	0.89	0.88
72	0.90	0.87
Amb
24	0.68	ND
48	0.43	0.32
72	0.31	0.54

^aMICs were read at 24 h (zygomycetes), 72 h (Scedosporium sp.), and 48 h (other species) as recommended in the CLSI M38-A document. Caspofungin MECs were read at 24 h (all species except for Scedosporium sp., which were read at 48 h). Each MIC or MEC was plotted against inhibition zone diameters in millimeters obtained on both MH and MGM agars at each of the three incubation times; results from three centers were combined for linear regression analysis.

^bItra, itraconazole 10-μg disk; Posa, posaconazole 5-μg disk; Cas-BBL and Cas-Oxoid, caspofungin 5-μg disks from two sources; Vori-1 and Vori-10, voriconazole 1-μg and 10-μg disks, respectively; Amb, amphotericin B 10-μg disk.

^cND, not determined. The 48-h results for MGM medium encompassed 24- and 48-h zones of inhibition; 71% of the 24-h results were reported as no growth.