TABLE 1.

Clinical and microbiological data for the six patients with true invasive zygomycosis

Characteristic	Patient no.
	1	2	3	4	5	6
Clinical form	Rhinosinusal	Rhinosinusal	Pulmonary and cutaneous	Pulmonary	Cutaneous-facial	Cutaneous-abdominal
Underlying condition
Neutropenia	Yes	No	Yes	Yes	No	No
Hematological malignancies	Yes (acute myeloid leukemia)	Yes (chronic lymphatic leukemia and BMTa)	Yes (acute myeloid leukemia)	Yes (lymphatic leukemia)	Yes (non-Hodgkin's lymphoma)	No
Transplant	No	Yes	No	No	No	Yes (liver)
Diabetes	No	No	No	No	Yes	No
Imaging data (X ray, CT scan, NMRb)	Yes	Yes	Yes	Yes	No	No
Previous immunosuppressive treatment	Yes	Yes	Yes	Yes	No	Yes
Previous antifungal treatment (30 days previously)	No	Yes (voriconazole)	No	No	No	No
Previous antibiotic treatment (30 days previously)	No	Yes	No	Yes	No	Yes
Previous corticosteroid treatment	No	No	No	No	Yes	No
Samples	Rhinosinusal sample	None	Wound	Sputum (n = 3)	None	Skin biopsy
Histopathology	Not done	Presence of hyphae	Not done	Not done	Presence of hyphae	Presence of hyphae
Culture result	Mucor sp.	Not done	Rhizomucor sp.	Cunninghamella bertholletiae	Not done	Mucor sp.
Diagnostic method	Clinical and culture	Clinical and histopathology	Clinical and culture	Clinical and culture	Clinical and histopathology	Clinical, culture and histopathology
Outcome	Cured	Death	Death	Death	Death	Cured

^aBMT, bone marrow transplant.

^bCT, computed tomography; NMR, nuclear magnetic resonance.