Table 1.

Representing query and modeling options for resources

	SNPs3D	PolyPhen	topoSNP	SNPeffect	LS-SNP	MutDB	SNP@Domain	Snap	StSNP
Keyword search is available	Yes	No	No	Yes	No	Yes	No	Yes	Yes
Modeling is available	Yes (precomputed)	No	Yes (precomputed)	No	Yes (precomputed)	No, mutations are highlighted in the structure	No, highlighting the amino acids affected by SNPs.	No	Yes (on the fly)
Pathway Information	Yes	No	No	No	Yes	No	No	Gene relations are available	Yes
Search by Protein ID	Yes	Yes	No	Yes	Yes	Yes	No	Yes	Yes
Search by FASTA sequence	No	Yes	Yes	No	No	No	No	No	No
Search by PDB ID	Yes	No	No	Yes	No	No	No	No	Yes
Analysis of nsSNPs	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No	No
Connection with OMIM or nsSNP info	Yes	Yes	Yes	Yes	Yes	No	Yes	Yes	No
Graphic display of the nsSNPs on protein sequence	No	No	No	No	No	Yes	Yes	Yes	Yes
Search by pathways	No	No	No	No	Yes	No	No	No	Yes
Disease Related info available	Yes	Yes	Yes	Yes	Yes	No	Yes(link to OMIM)	Yes	No
Domain info for the proteins	No	Yes (links available)	No	Yes (links available)	Yes (link to SCOP)	No	Yes	Yes	No
Search by rs#	Yes	Yes	No	Yes	Yes	Yes	Yes	Yes	Yes
Search by gene	Yes	No	No	Yes	Yes	Yes	Yes	Yes	Yes