FIG. 8.
Sequence and predicted secondary-structure similarities between ORFV125 and Bcl-2 family members. Amino acid sequence alignment of ORFV125 with three antiapoptotic Bcl-2 family members, Bcl-xL, Bcl-2, and Bcl-w. BH domains of Bcl-xL are shown as colored boxes, and the TM domain is shown as a gray box. Positions of the Bcl-xL α-helices (α1 to -6, -6′, and -7) (Jpred) are represented as black chains above the alignment, while the predicted α-helices for ORFV125 (pα1 to -7) are plotted below the alignment in blue. Amino acids conserved in all four sequences are marked with black boxes showing amino acids identical to ORFV125 and gray boxes indicating conserved substitutions (according to ClustalW).