TABLE 1.
PrP genotypes and survival times for sheep challenged with scrapie (i.c. or orally) or BSE (i.c.)
| PrP genotype and disease challenge | No. of affected sheep/no. of inoculated sheep | Mean survival time ± SD (days) |
|---|---|---|
| i.c. scrapie transmission | ||
| ARQ/ARQ | 5/5 | 462 ± 25 |
| ARQ/AHQ | 5/5 | 703 ± 36 |
| AHQ/AHQ | 1/1 | 790 |
| ARQ/ARH | 1/1 | 1,083 |
| AHQ/ARH | 3/3 | 1,252 ± 87 |
| ARQ/ARR | 0/13 | >1,450 |
| AHQ/ARR | 0/1 | >1,450 |
| ARH/ARR | 0/1 | >1,450 |
| ARR/ARR | 0/5 | >1,450 |
| AT137RQ/ARQK176 | 0/1 | >1,450 |
| ARQK176/AHQ | 0/1 | >1,450 |
| ARQK176/ARR | 0/2 | >1,450 |
| Oral scrapie transmission | ||
| ARQ/ARQ | 5/5 | 860 ± 16 |
| ARQ/AHQ | 5/5 | 1,115 ± 159 |
| ARQ/ARH | 0/3 | >1,550 |
| ARQ/ARR | 0/10 | >1,550 |
| ARH/ARR | 0/1 | >1,550 |
| ARR/ARR | 0/5 | >1,550 |
| ARQ/AT137RQ | 0/3 | >1,550 |
| ARQ/ARQK176 | 0/1 | >1,550 |
| ARQ/AK142RQ | 0/1 | >1,550 |
| ARQK176/ARR | 0/1 | >1,550 |
| i.c. BSE transmission | ||
| ARQ/ARQ | 2/2 | 480 ± 2 |
| ARQ/ARH | 2/2 | 748 ± 18 |
| ARQ/ARR | 0/5 | >950 |
| AHQ/ARR | 0/1 | >950 |
| ARR/ARR | 0/7 | >950 |
| ARQ/AT137RQ | 0/3 | >950 |
| ARQK176/AHQ | 0/1 | >950 |
| AT137RQ/AHQ | 0/1 | >950 |
| AT137RQ/ARH | 0/1 | >950 |
| AT137RQ/ARR | 0/3 | >950 |