Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Location of the TS mutation on the nsp10 structure. A homology model of the MHV-A59 nsp10 protein was generated using the coordinates of the X-ray crystal structure of SARS-CoV (PDB accession number 2FYG) using the program Modeler. The mutants icTS-LA6 (nsp10:Q65E) and nsp10-E2 (nsp10:D47A,H48A) were mapped onto the structure. Both mutations occur within a predicted disordered region, proximal to zinc-binding finger 1, and are exposed to the surface.
