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Differential effects of estrogen on PRL expression and cell proliferation. PR1 cells were incubated with either 1 nM of E2 or DES alone, or with 1-, 10-, or 100-fold more ICI. (A) [3H]Thymidine incorporation (mean ± SD of quadruplicate samples) and (B) secreted PRL were analyzed. Solid line, no addition. One representative data of three.
