TABLE 7.

HSV-1 WT and tk mutants detected in individual neurons from a ganglion of patient 708

Composition of virus population in single neurons (% of total no. of neurons)	Single neurona identification	No. of clones sampled	No. of clonesb with:					% of mutant clones
			7-G (WT) sequence	1-G del	1-G ins	2-G ins	3-G ins
Both WT and mutant clones in	sn-1	16	12			4		25
each neuron (42.9)	sn-2	17	16			1		6
	sn-3	16	12			4		25
	sn-4	21	7			14		67
	sn-5	24	5		1	16	2	79
	sn-6	17	16	1				5.9
WT only in each neuron (28.6)	sn-7	13	13					0.0
	sn-8	6	6					0.0
	sn-9	23	23					0.0
	sn-10	10	10					0.0
Mutants only in each neuron (28.6)	sn-11	13				13		100
	sn-12	21				18	3	100
	sn-13	22			2	20		100
	sn-14	10			1	9		100

^aSingle neurons were retrieved from LT9 DRG tissue sections by LCM.

^bdel, deletion; ins, insertion.