FIG. 1.

Hematological findings. ANDV and SNV serial pathogenesis groups were analyzed for changes in hematological parameters after infection. The area between dotted lines represents the normal reference range for hamsters. ANDV-infected animals exhibited white blood cell (WBC) counts above normal reference values (A) with a corresponding increase in the percent segmented neutrophils (%SEG) beginning on day 10 (B). (C and D) Lymphopenia (%LY) and thrombocytopenia (Plt) were also observed with ANDV infection, although similar changes were also observed with SNV that occurred later and to a lesser degree. (E and F) Slight rises in red blood cell (RBC) and hematocrit (Hct) were also observed with ANDV and SNV but remained within normal limits. Symbols represent the mean values for each time point. Error bars represent the standard errors of the means (SEM). Asterisks represent statistically significant (P < 0.05) differences relative to day −7 values.