FIG. 3.

Immunohistochemistry of SNV-infected hamsters. An immunoperoxidase-based immunohistochemical assay using anti-nucleocapsid antibody was performed on tissues from SNV-infected animals (Table 2). Immunopositive cells (presumably endothelial cells) were found rarely in multiple organs of SNV-infected hamsters at late times during infection (day 14). Only individual antigen-positive cells were observed, while ubiquitous endothelial cell staining was observed with ANDV. Representative samples include heart of animal 260 (A), kidney of animal 260 (B), lung of animal 260 (C), and brain of animal 261 (D). All images were acquired at a magnification of ×60. Arrows are shown in all images to highlight antigen-positive cells.