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Spm8CHAS prevents HSV infection of cervical explants. Cervical explant cultures were exposed to 107 PFU/explant HSV-2(G) in the absence or presence of the indicated concentration of drug. Supernatants were collected 7 days postinfection and assayed for HSV by plaque assay on ME180 cells. Results are presented as PFU formed in the presence of drug as a percentage of PFU formed in the presence of medium alone and are means ± SEM obtained from three experiments conducted in triplicate.
