TABLE 5.
Cellular pathways with greater-than-chance representation by signature proteinsa
| Analyzer | Pathway | Expectation |
|---|---|---|
| GeneGo MetaCore | RAN regulation pathway | 3.55 × 10−3 |
| Role of APC in cell cycle regulation | 4.96 × 10−3 | |
| Ligand-dependent transcription of retinoid-target genes | 7.68 × 10−3 | |
| Oxidative phosphorylation | 1.02 × 10−2 | |
| Role of 14-3-3 proteins in cell cycle regulation | 1.50 × 10−2 | |
| Role of Akt in hypoxia-induced HIF1 activation | 1.79 × 10−2 | |
| TCA | 2.64 × 10−2 | |
| Ingenuity | Protein ubiquitination pathway | 6.20 × 10−3 |
| Citrate cycle | 1.08 × 10−2 | |
| Valine, leucine, and isoleucine degradation | 2.52 × 10−2 | |
| ERK/MAPK signaling | 3.04 × 10−2 |
a
Shown are pathways with less than 5% expected chance of occurrence. Pathways were revealed by GeneGo MetaCore and Ingenuity Pathways Analysis. APC, anaphase-promoting complex.