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. 2007 Jul 10;7:83. doi: 10.1186/1471-213X-7-83

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Copyright © 2007 Sheeba et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Proposed model for Hairy1-mediated transcriptional repression in the prospective somite and caudal region of somites. In the prospective somite and caudal region of already formed somites, where sap18, sin3a and hairy1 expression co-localize, a homo- or hetero-dimer containing Hairy1, bound to specific promoter regulatory sequences, may interact with Sap18 through the Hairy1 C-terminal domain and recruit the Sin3/HDAC complex to the transcriptional site, thus repressing target gene expression.