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. Author manuscript; available in PMC: 2007 Jul 26.
Published in final edited form as: Nucl Med Biol. 2007 Mar 30;34(4):353–361. doi: 10.1016/j.nucmedbio.2007.01.012

Table 1.

Chemical Characteristics of the CRF1 Radioligands

Radioligand Molecular Weight Calculated Log P Value Ki (nM)b Synthesis Time (min) Yield (%)c SA (Ci/µmol)d
[11C]R121920 367 4.0a 4.0 30 5 >1000
[11C]DMP696 410 3.2e 1.7 30 25 >2000
[11C]SN003 356 3.1e 4.0 30 22 >2000
a

Calculated with ACD/ logP DB program

b

Of the unlabeled antagonist [44, 52, 53]

c

At the end of synthesis (EOS)

d

SA = specific activity measured at end of bombardment (EOB)

e

Determined by shake‐flask method