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(A) Neighboring 15-exon PIP5K1A and 10-exon S5a genes on Chr 1 are spliced to form PIP5K1A, S5a, and PIP5K1A-S5a TIC mRNAs. (Black rectangles) Exons; (curved lines) splicing. (B) PIP5K1A-S5a TIC was retrotransposed by L1 to create the PIPSL gene on Chr 10. (TSD) Target site duplication; (pA) A-rich repeat. (White rectangles) Regions corresponding to PIP5K1A exons; (gray rectangles) regions corresponding to S5a exons.
