Table 5.
Comparisons of the parameters of the IAHG scoring system among patients with chronic liver diseases* (n = 423), AIH/overlap syndromes (n = 10) and patients with coincidence of AIH and other liver disease (n = 14).
| Characteristics | Patients with liver diseases* no. of patients (%) | Patients with AIH/overlap syndromes no. of patients (%) | Patients with coincidence of AIH and other liver disease no. of patients (%) | P value |
| Gender | ||||
| Female | 231 (54.6) | 5 (50) | 7 (50) | NS |
| Male | 192 (45.4) | 5 (50) | 7 (50) | |
| ALP/ALT ratio | ||||
| Positive: score +2 | 338 (79.9) | 8 (80) | 12 (85.7) | NS |
| Negative: score 0, -2 | 85 (20.1) | 2 (20) | 2 (14.3) | |
| Serum globulin or IgG above normal | ||||
| Positive (score ≥ 1) | 202 (47.8) | 7 (70) | 10 (71.4) | NS |
| Negative (score 0) | 221 (52.2) | 3 (30) | 4 (28.6) | |
| ANA, SMA or anti-LKM | ||||
| Positive (titre ≥ 1:40) | 335 (79.2) | 9 (90) | 14(100) | NS |
| Negative | 88 (20.2) | 1 (10) | 0 | |
| AMA | ||||
| Positive (titre ≥ 1:40) | 49 (11.6) | 4 (40) | 0 | 0.009** |
| Negative | 374 (88.4) | 6 (60) | 14(100) | |
| Hepatitis viral markers | ||||
| Yes | 216 (51.1) | 0 | 8 (57.1) | 0.005** |
| No | 207 (48.9) | 10 (100) | 6 (42.9) | |
| History of illicit drug use | ||||
| Yes | 25 (5.9) | 0 | 0 | NS |
| No | 398 (94.1) | 10 (100) | 14 (100) | |
| Average alcohol intake | ||||
| <25 g/day | 325 (76.8) | 10 (100) | 11 (78.6) | 0.013** |
| >60 g/day | 98 (23.2) | 0 | 3 (21.4) | |
| Histological score | ||||
| Positive (score > 0) | 58 (13.7) | 3 (30) | 10 (71.4) | <0.001** |
| Negative (score ≤ 0) | 365 (86.3) | 7 (70) | 4 (28.6) | |
| Aggregate histological score (mean ± SD) | -4± 3.3 | -2.1± 4.4 | 2.14± 1.7 | <0.001*** |
| Other autoimmune disease | ||||
| Yes | 24 (5.7) | 5 (50) | 2 (14.3) | <0.001** |
| No | 399 (94.3) | 5 (50) | 12 (85.7) | |
| Aggregate AIH score (mean ± SD) | 2.5 ± 4.23 | 9.3 ± 4.8 | 10.5 ± 3.7 | <0.001*** |
Abbreviations are same as in text; NS: not statistically significant; SD: standard deviation; *Excluding AIH patients (n = 43) and patients with coincidence of AIH and any kind of liver disorder (n = 24); **Total x square (comparison amongst the three groups of patients; for statistical significance between groups see text of results; subheading Comparison between groups, second paragraph); ***Kruskal-Wallis test (comparison amongst the three groups of patients; for statistical significance between groups see text of results, subheading Comparison between groups, second paragraph).