Table 1.
Effect of each polymorphic SNP on each of the cognitive outcomes, controlling for sex and age 11 cognitive ability.
| Moray House Test | Raven's Progressive Matrices | Verbal Fluency | Logical Memory | ||
| Gene | SNP | ||||
| AGER | rs3134943 | .770 | .808 | .058 | .773 |
| rs1800684 | .701 | .738 | .036 | .773 | |
| APOD | rs6786696 | .982 | .930 | .680 | .807 |
| rs17033096 | .748 | .683 | .527 | .610 | |
| rs4686327 | .580 | .959 | .761 | .419 | |
| APP | rs1787439 | .817 | .409 | .065 | .112 |
| rs2040276 | .094 | .725 | .108 | .246 | |
| rs2026225 | .736 | .818 | .770 | .142 | |
| rs2830019 | .948 | .443 | .809 | .106 | |
| rs2830020 | .948 | .443 | .809 | .106 | |
| rs2830038 | .284 | .636 | .076 | .075 | |
| rs1041420 | .022 | .346 | .389 | .148 | |
| rs2830045 | .463 | .366 | .398 | .669 | |
| rs2830048 | .247 | .789 | .233 | .052 | |
| rs2830052 | .016 | .051 | .932 | .405 | |
| rs3787650 | .669 | .667 | .871 | .823 | |
| rs2830071 | .474 | .903 | .469 | .119 | |
| rs2830102 | .003 | .016 | .978 | .436 | |
| BACE | rs535860 | .994 | .777 | .416 | .610 |
| rs638405 | .541 | .184 | .985 | .359 | |
| CAT | rs769217 | .304 | .804 | .121 | .921 |
| CBS | rs234706 | .149 | .299 | .846 | .676 |
| CDKN1B | rs3093728 | .677 | .767 | .286 | .263 |
| rs34330 | .088 | .522 | .413 | .034 | |
| rs4251698 | .632 | .589 | .439 | .328 | |
| rs7330 | .901 | .782 | .231 | .880 | |
| CHRM2 | rs8191992 associated with IQ [60]. | .156 | .610 | .796 | .781 |
| CP | rs16861582 | .020 | .228 | .728 | .318 |
| rs1053709 | .684 | .682 | .667 | .606 | |
| rs6799507 | .770 | .859 | .061 | .854 | |
| rs701753 | .576 | .325 | .157 | .682 | |
| rs17838831 | .155 | .103 | .786 | .027 | |
| CRYAB | rs4252581 | .376 | .683 | .243 | .789 |
| rs14133 | .931 | .546 | .696 | .552 | |
| rs4252583 | .097 | .010 | .394 | .184 | |
| rs762550 | .344 | .713 | .622 | .073 | |
| CSNK1D | rs6416862 | .338 | .506 | .010 | .814 |
| CTSD | rs17571 associated with AD [61] and general intelligence [62]. | .355 | .402 | .958 | .333 |
| CTSH | rs13345 | .312 | .964 | .118 | .589 |
| rs12148472 | .700 | .944 | .318 | .406 | |
| rs1036938 | .835 | .509 | .131 | .916 | |
| CTSS | rs10888390 | .322 | .557 | .259 | .127 |
| CTSZ | rs9760 | .623 | .387 | .011 | .082 |
| DNAJB1 | rs3962158 | .081 | .295 | .216 | .716 |
| DNAJB2 | rs2276638 | .283 | .639 | .794 | .321 |
| rs3731897 | .287 | .546 | .793 | .383 | |
| FOSB | rs2282695 | .661 | .938 | .317 | .762 |
| rs2238686 | .073 | .036 | .676 | .849 | |
| FOXO3A | rs12202049 | .851 | .557 | .782 | .933 |
| rs2883881 | .831 | .952 | .250 | .098 | |
| rs17532874 | .814 | .848 | .475 | .510 | |
| rs12203787 | .887 | .473 | .842 | .892 | |
| GCLC | rs1555903 | .659 | .336 | .420 | .295 |
| GFAP | rs3744473 | .620 | .275 | .362 | .674 |
| rs3744470 | .782 | .716 | .890 | .420 | |
| rs9916491 | .620 | .275 | .362 | .674 | |
| rs1126642 | .669 | .187 | .295 | .321 | |
| GLRX | rs4561 | .254 | .560 | .182 | .003 |
| GPX1 | rs3448 | .731 | .135 | .660 | .464 |
| GSR | rs2251780 | .232 | .664 | .788 | .860 |
| GSS | rs6119545 | .019 | .029 | .073 | .299 |
| rs7265992 | .238 | .412 | .193 | .619 | |
| rs2025096 | .999 | .897 | .963 | .614 | |
| GSTA2 | rs6577 | .683 | .052 | .908 | .492 |
| rs2180314 | .662 | .116 | .395 | .500 | |
| GSTA4 | rs1802061 | .268 | .810 | .365 | .982 |
| GSTA5 | rs2397118 | .599 | .960 | .763 | .677 |
| GSTM3 | rs7483 | .722 | .926 | .736 | .488 |
| GSTM4 | rs560018 | .747 | .619 | .842 | .773 |
| rs650985 | .763 | .756 | .686 | .717 | |
| GSTO1 | s4925 | .344 | .971 | .847 | .119 |
| GSTO2 | rs156697 | .619 | .726 | .405 | .028 |
| rs3758572 | .670 | .553 | .407 | .754 | |
| GSTP1 | rs762803 | .258 | .969 | .712 | .688 |
| rs947894 | .206 | .302 | .745 | .395 | |
| rs1799811 | .436 | .528 | .110 | .171 | |
| rs1871042 | .269 | .500 | .987 | .461 | |
| GSTT2 | rs140188 | .266 | .382 | .070 | .297 |
| GSTZ1 | rs2270421 | .072 | .203 | .178 | .847 |
| rs2287395 | .159 | .288 | .174 | .667 | |
| rs3177429 | .245 | .507 | .533 | .737 | |
| rs2287396 | .267 | .083 | .884 | .268 | |
| rs1046428 | .312 | .511 | .191 | .663 | |
| HMOX2 | rs6500610 | .635 | .364 | .275 | .215 |
| rs11643057 | .733 | .411 | .666 | .363 | |
| rs17137094 | .010 | .011 | .189 | .675 | |
| HSPA12A | rs1665659 | .443 | .454 | .067 | .362 |
| rs4752003 | .030 | .010 | .619 | .689 | |
| rs1665638 | .783 | .645 | .270 | .293 | |
| rs740599 | .585 | .630 | .865 | .758 | |
| rs1900501 | .247 | .025 | .435 | .190 | |
| HSPA12B | rs3827077 | .121 | .689 | .473 | .190 |
| rs6076550 | .493 | .505 | .828 | .870 | |
| rs2295340 | .516 | .725 | .462 | .612 | |
| HSPA1L | rs2075800 | .133 | .371 | .267 | .845 |
| HSPA2 | rs17101915 | .493 | .583 | .051 | .249 |
| rs11848114 | .251 | .615 | .109 | .110 | |
| HSPA4 | rs398606 | .680 | .021 | .216 | .775 |
| rs14355 | .096 | .062 | .716 | .246 | |
| HSPA5 | rs430397 | .348 | .413 | .084 | .825 |
| HSPA8 | rs3763897 | .349 | .020 | .119 | .960 |
| HSPA9B | rs10117 | .006 | .211 | .261 | .267 |
| HTR2A | rs3803189 | .128 | .118 | .984 | .910 |
| rs6314 associated with episodic memory [63]. | .096 | .180 | .429 | .388 | |
| rs1923884 | .966 | .601 | .948 | .773 | |
| rs6305 | .151 | .746 | .926 | .133 | |
| rs6313 associated with AD [64]. | .209 | .079 | .996 | .885 | |
| IDE | rs7895832 | .181 | .093 | .690 | .470 |
| rs3758505 associated with AD [65]. | .181 | .093 | .690 | .470 | |
| IL1B | rs1143634 associated with AD [66]. | .372 | .082 | .738 | .450 |
| rs16062 | .508 | .404 | .711 | .484 | |
| rs1143627 | .591 | .872 | .354 | .926 | |
| LTF | rs4683233 | .220 | .073 | .826 | .023 |
| MPO | rs2759 | .500 | .154 | .634 | .301 |
| rs7208693 | .959 | .940 | .782 | .945 | |
| MSRA | rs12679328 | .950 | .072 | .466 | .063 |
| rs3735823 | .985 | .087 | .833 | .245 | |
| rs814422 | .237 | .111 | .462 | .584 | |
| rs1994224 | .460 | .078 | .592 | .414 | |
| rs6601414 | .034 | .386 | .211 | .717 | |
| rs17151140 | .396 | .191 | .876 | .567 | |
| rs1484645 | .609 | .343 | .252 | .039 | |
| rs6986977 | .510 | .907 | .764 | .261 | |
| rs877390 | .661 | .389 | .544 | .690 | |
| rs7845503 | .437 | .936 | .722 | .020 | |
| rs6992349 | .956 | .718 | .292 | .573 | |
| rs4288376 | .189 | .373 | .503 | .250 | |
| rs10503405 | .965 | .353 | .263 | .871 | |
| rs6983870 | .271 | .246 | .432 | .265 | |
| rs4260895 | .263 | .069 | .341 | .154 | |
| rs2952182 | .355 | .612 | .586 | .832 | |
| rs11783821 | .437 | .523 | .149 | .586 | |
| rs17151588 | .204 | .360 | .309 | .214 | |
| rs7832708 | .233 | .151 | .899 | .021 | |
| rs4841322 | .746 | .663 | .882 | .400 | |
| rs4841324 | .706 | .644 | .849 | .435 | |
| MSRB2 | rs10764383 | .951 | .540 | .043 | .272 |
| rs11013295 | .862 | .668 | .404 | .354 | |
| rs7427 | .006 | .111 | .487 | .550 | |
| NDRG1 | rs2977499 | .536 | .626 | .436 | .829 |
| rs2272653 | .970 | .517 | .812 | .184 | |
| rs2930002 | .961 | .599 | .502 | .543 | |
| NDUFA10 | rs2083411 | .594 | .085 | .809 | .255 |
| NDUFA3 | rs254259 | .021 | .020 | .517 | .269 |
| NDUFA6 | rs1801311 | .630 | .207 | .074 | .036 |
| NDUFA7 | rs561 | .417 | .734 | .077 | .754 |
| rs2241591 | .239 | .180 | .366 | .774 | |
| NDUFA8 | rs4147659 | .180 | .585 | .584 | .574 |
| rs6822 | .238 | .634 | .690 | .646 | |
| rs4679 | .079 | .592 | .405 | .389 | |
| NDUFA9 | rs4147672 | .611 | .387 | .825 | .723 |
| rs4147682 | .611 | .387 | .825 | .723 | |
| NDUFAB1 | rs459894 | .620 | .580 | .948 | .070 |
| NDUFAF1 | rs3204853 | .294 | .162 | .506 | .566 |
| NDUFB10 | rs2302175 | .129 | .533 | .878 | .373 |
| NDUFB5 | rs2339844 | .590 | .320 | .894 | .083 |
| NDUFB7 | rs9543 | .676 | .552 | .081 | .032 |
| NDUFB8 | rs1800662 | .354 | .447 | .709 | .738 |
| NDUFB9 | rs11547284 | .483 | .023 | .690 | .840 |
| NDUFS1 | rs11548670 | .166 | .258 | .002 | .287 |
| rs4147707 | .977 | .610 | .613 | .993 | |
| NDUFS2 | rs3813624 | .225 | .973 | .255 | .783 |
| rs16832694 | .490 | .890 | .878 | .229 | |
| rs16832699 | .225 | .973 | .255 | .783 | |
| rs11587213 | .957 | .200 | .293 | .925 | |
| NDUFS4 | rs4147732 | .727 | .369 | .422 | .516 |
| rs2279516 | .710 | .876 | .073 | .240 | |
| rs13156337 | .417 | .608 | .468 | .075 | |
| rs31304 | .451 | .409 | .938 | .341 | |
| rs31303 | .783 | .260 | .609 | .885 | |
| rs567 | .688 | .190 | .226 | .641 | |
| NDUFS6 | rs3776141 | .329 | .561 | .117 | .011 |
| NDUFV2 | rs906807 | .346 | .009 | .892 | .732 |
| NDUFV3 | rs4148973 | .718 | .473 | .0003 | .559 |
| rs8128440 | .710 | .500 | .0002 | .742 | |
| NOS1 | rs9658501 | .278 | .275 | .696 | .799 |
| rs3741475 | .556 | .447 | .469 | .212 | |
| rs10774909 | .393 | .138 | .533 | .338 | |
| rs9658446 | .062 | .186 | .249 | .004 | |
| rs2293054 | .443 | .289 | .893 | .718 | |
| rs11612772 | .659 | .255 | .253 | .737 | |
| rs561712 | .795 | .719 | .870 | .628 | |
| rs9658256 | .661 | .270 | .405 | .089 | |
| NOS2A | rs2297512 | .187 | .471 | .553 | .164 |
| rs2297518 | .504 | .285 | .556 | .254 | |
| rs1137933 | .455 | .429 | .206 | .428 | |
| rs3730017 | .318 | .955 | .342 | .373 | |
| NOS3 | rs1549758 | .179 | .489 | .620 | .463 |
| rs1799983 associated with mild cognitive impairment [67]. | .380 | .263 | .779 | .258 | |
| rs2566514 | .738 | .774 | .876 | .298 | |
| rs3918232 | .612 | .092 | .226 | .546 | |
| NR2C2 | rs17536979 | .480 | .367 | .719 | .206 |
| rs648912 | .957 | .489 | .849 | .358 | |
| PLAU | rs2227564 associated with AD [68]. | .766 | .877 | .796 | .623 |
| rs2227567 | .121 | .816 | .508 | .440 | |
| rs2227568 | .974 | .696 | .053 | .886 | |
| rs4065 | .459 | .953 | .120 | .293 | |
| PON2 | rs6954345 | .054 | .261 | .510 | .788 |
| rs10487133 | .294 | .661 | .510 | .686 | |
| rs11545941 | .054 | .261 | .510 | .788 | |
| rs17166875 | .054 | .261 | .510 | .788 | |
| PRDX1 | rs6667191 | .912 | .697 | .763 | .689 |
| PRDX2 | rs10413408 | .824 | .251 | .445 | .773 |
| rs10422248 | .824 | .251 | .445 | .773 | |
| PRDX4* | rs552105 (male) | .611 | .942 | .495 | .509 |
| rs552105 (female) | .856 | .569 | .894 | .898 | |
| rs1548734 (male) | .611 | .942 | .495 | .509 | |
| rs1548734 (female) | .832 | .515 | .891 | .870 | |
| SAA2 | rs2468844 | .558 | .557 | .676 | .596 |
| SEPP1 | rs6413428 | .073 | .055 | .948 | .307 |
| rs7579 | .616 | .677 | .851 | .786 | |
| SIRT1 | rs2273773 | .967 | .517 | .358 | .730 |
| rs2234975 | .937 | .840 | .454 | .750 | |
| SLC25A27 | rs9369628 | .383 | .213 | .990 | .646 |
| rs12192544 | .881 | .251 | .989 | .739 | |
| rs3757241 | .126 | .975 | .304 | .739 | |
| SOD2 | rs1799725 | .381 | .937 | .438 | .111 |
| SOD3 | rs1799895 | .485 | .813 | .745 | .924 |
| TF | rs1130459 | .153 | .069 | .260 | .311 |
| rs1799852 | .685 | .237 | .149 | .919 | |
| rs1799899 | .789 | .722 | .454 | .835 | |
| rs1049296 | .434 | .899 | .829 | .621 | |
| rs3811656 | .087 | .025 | .248 | .796 | |
| TXN | rs4135162 | .157 | .747 | .929 | .289 |
| TXN2 | rs2281082 | .951 | .220 | .864 | .253 |
| TXNRD1 | rs11111979 | .755 | .026 | .399 | .709 |
| rs7134193 | .850 | .101 | .314 | .737 | |
| rs4964287 | .924 | .205 | .035 | .615 | |
| TXNRD2 | rs3827288 | .585 | .211 | .136 | .471 |
| rs5992495 | .879 | .865 | .209 | .056 | |
| rs5748469 | .577 | .780 | .232 | .832 | |
| rs5746847 | .388 | .983 | .125 | .691 | |
| TXNRD3 | rs777241 | .993 | .767 | .270 | .498 |
| UCP2 | rs660339 | .578 | .723 | .520 | .372 |
| VEGF | rs2010963 | .980 | .766 | .372 | .228 |
| rs833068 | .974 | .765 | .434 | .205 | |
| rs3025000 | .849 | .828 | .408 | .227 | |
| rs3025010 | .192 | .935 | .267 | .161 | |
| rs3025039 | .112 | .130 | .882 | .230 | |
| rs3025053 | .487 | .326 | .705 | .620 | |
| VIM | rs1049341 | .336 | .976 | .815 | .887 |
p values are given. p values < 0.01 are in bold. SNPs previously associated with intelligence or AD are indicated.
*PRDX4 is located on the X chromosome and therefore men and women were analyzed separately.