Table 3.
Effect of SNPs showing a significant (p < 0.01) association with at least one cognitive trait at age 79 (LBC1921), controlling for sex and age 11 cognitive ability, on cognitive traits at age 64 (ABC1936), controlling for sex and age 11 cognitive ability.
| No. of subjects with each genotype | BD | DS | RM | UCO | AVLT | ||||
| Gene | SNP | A/A | A/B | B/B | |||||
| APP | rs2830102 | 29 | 168 | 167 | .380 | .855 | .345 | .167 | .984 |
| GLRX | rs4561 | 128 | 171 | 66 | .465 | .426 | .391 | .044 | .848 |
| HSPA9B | rs10117 | 56 | 180 | 142 | .433 | .963 | .012 | .841 | .698 |
| MSRB2 | rs7427 | 41 | 164 | 174 | .451 | .585 | .813 | .484 | .650 |
| NDUFS1 | rs11548670 | 351 | 25 | 1 | .570 | .113 | .956 | .395 | .144 |
| NDUFV2 | rs906807 | 11 | 102 | 256 | .953 | .749 | .783 | .410 | .672 |
| NDUFV3 | rs8128440 | 145 | 178 | 41 | .856 | .903 | .509 | .146 | .515 |
p values are given.
Key: BD = Block Design, DS = Digit Symbol, RM = Raven's Progressive Matrices, UCO = Use of Common Objects, AVLT = Auditory Verbal Learning Test