Table I.

Review of the literature on postnatal follow-up in children that had increased nuchal translucency (NT) with normal karyotype at 11–14 weeks of gestation

	Population	Cut-off value for NT	Prevalence of increased NT and normal karyotype	Liveborn neonates	Method of assessment of child development	Postnatal follow-up (months)	Lost for follow-up	Developmental delay * n(%) and 95%CI
Van Vugt (7)	NA	3.0mm	NA	50	Questionnaire	33.5 (7–75)	32%	1/34 (2.9%) [0%–15%]
Adekunle (8)	Screening	4.0mm	0.8%	31	Questionnaire	23.0 (13–38)	26%	2/23 (8.7%) [l%–28%]
Maymon (9)	Referral	95th centile	NA	36	Telephone	24 (12–36)	0%	0/36 (0%) [0%–10%]
Brady (10)	Referral	3.5mm	NA	90	Clinical examination	NA 6–42	1.1%	1/89 (1.1%) [0%–6%]
Hippala (11)	Screening	3.0mm	0.8%	59	Clinical examination	56 (24–84)	15%	1/50 (2.0%) [0%–11%]
Senat (12)	Referral	4.0mm	NA	58	Clinical examination	39 (12–72)	7%	3/54 (5.6%) [1%–15%]
Cheng (13)	Screening	3.0mm	0.74%	14	Clinical examination/Telephone	21 (8–30)	0	1/14 (7.1%) [0%–34%]
Souka (14)	Referral	3.5mm	NA	980	NA	NA	0	4/980 (0.4%) [0.1%–1%]

^*% and 95% confidence interval are calculated from the original article

NA: not available