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. 2007 Aug 8;2(8):e709. doi: 10.1371/journal.pone.0000709

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Lafourcade et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Typical experiment showing that a 5 min stimulation at 10 Hz is sub threshold to induce LTD, even when applied two consecutives times. Calibration bars: x: 10 ms, y: 0.2 mV. (B) Representative experiment showing that 5 min at 10 Hz can induce LTD when applied after bath perfusion with URB 602 (100 µM). Traces were taken at the time indicated on corresponding graph. Calibration bars: x: 10 ms, y: 0.2 mV. (C) Summary bar histogram of all the experiments performed where the first tetanus was given in saline and the second tetanus was given after bath perfusion of URB602. LTD was induced only when URB was present (t-test, p = 0.0271). (D) Averaged time courses of the experiments in which the 5min at 10Hz protocol was given in control ACSF (open circles) of after pre-treatment with URB597 (2 µM, black triangles) or URB602 (black circles).