Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for S/MAR associations in GABAA receptor subunit gene locus. (a) Gene locus anchored to nuclear matrix by flanking S/MARS (red) establishes open chromatin conformation. (b) Functional S/MAR mediates loop attachment to transcriptional machinery (pink). (c) Chromatin is reeled through transcriptional machinery in either direction to activate transcription of β2 or α1 gene (d) functional S/MAR dissociates upon elongation. (After Martins et el [15], Heng et al [17]).
