Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Jul 27;3(7):e127. doi: 10.1371/journal.pgen.0030127

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

PMC Copyright notice

Graphed for each (human-to-mouse, -rabbit, -rat, and -dog) comparison in (A–D) are: the percentage of all TFBSs from each gene group (p53, 83 REs; NRF2, 21 REs; or NFκB, 21 REs) that fall within the x-axis conservation bins (red bars); data for randomly sampled fragments from human coding regions (blue bars); and gene promoters (gray bars). Coding regions (representing sequence under purifying selection) and randomly sampled promoter regions (representing sequence under more neutral selection) were sampled 1,000 trials; error bars are narrower than the line art. Averages and standard errors for the sets of known TFBSs are reported above each graph.