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. Author manuscript; available in PMC: 2008 Mar 1.
Published in final edited form as: Pharmacol Ther. 2006 Dec 28;113(3):546–593. doi: 10.1016/j.pharmthera.2006.11.007

Table 2.

Effects of GLP-1 on membrane potential of the β cell.

Resting Membrane Potential mV (Glucose Conc. mM) Stimulatory Concentration of Glucose Applied (mM) Concentration of GLP-1 Applied (nM) ΔΨ (mV) depolarization in membrane potential* System Used Reference
−62 (0) 10 10 30–35 Perforated patch; dispersedβ cells from Rat islet of Langerhans (Holz et al., 1993)
−50 (5) 10 10 10 Patch clamp; dispersed β cells from mouse islet of Langerhans (Gromada et al., 1997)
−53 (5) 5 20 6.7 Perforated patch; INS-1 cells (Light et al., 2002)
*

This is the depolarization that is observed in response to GLP-1 application over and above the extent of depolarization in response to glucose alone