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. 2007 Aug;171(2):589–598. doi: 10.2353/ajpath.2007.061241

Figure 8.

Figure 8

CNPase-positive oligodendroglial cells are associated with remyelination of naked axons expressing Nav1.2 sodium channels (A–D, red). A: At the onset of the disease (day 9 p.i), CNPase-expressing oligodendroglial cells (green, arrowheads) start to appear in the lesion. B: At the maximum of disease (day 13 p.i) contact Nav1.2-positive naked axons appear (arrowheads). C: In the later phase of MOG-EAE, CNPase-positive oligodendroglial cells surround and ensheathed demyelinated axons (arrowheads). D: Finally (day 40 p.i), irregular and thin myelin sheaths suggestive of remyelination can be seen (arrowheads). Representative sections from lumbar spinal cord are shown. D: Projection of 24 optical sections.