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Level of Skp2 mRNA measured by quantitative RT-PCR in the obstructed kidneys from Skp2+/+ wild-type mice at the experimental time points after UUO. In the obstructed kidneys from Skp2+/+ mice, mRNA expression of Skp2 markedly increased and peaked 3 days after UUO. *P < 0.05, **P < 0.005 versus sham-operated kidneys.
