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. 1996 Nov 26;93(24):13577–13582. doi: 10.1073/pnas.93.24.13577

Figure 1.

Figure 1

Comparison of ΔYY1 with other zinc-finger structures. (A) Amino acid sequence of ΔYY1. The zinc fingers are aligned one above the other, with the linker regions separated by vertical bars. Amino acids are numbered as in ref. 14. The ΔYY1–DNA contacts (Y1–Y4, •, backbone contact; +, base contact; =, touches both base and backbone) are also presented schematically with those seen in the structures of Zif268 (Z1–Z3) (18), GLI (G2–G5) (16), and Tramtrack (T1, T2) (21). Between the alignment panels, the zinc-finger consensus sequence (Ø, aromatic residue) and the conserved secondary structure elements are provided. Detailed comparisons of the ΔYY1 fingers with those of Zif268 and GLI reveal significant similarities [Y1 versus G3 root-mean-square deviation (rmsd) = 0.81 Å, Y2 versus Z3 rmsd = 0.61 Å, Y3 versus G3 rmsd = 0.73 Å, and Y4 versus G3 rmsd = 0.68 Å, which compare favorably with comparisons between Zif268 and GLI]. (B) Schematic comparison of the DNA contacts made by Zif268, GLI, and ΔYY1. DNA bases and backbone are represented by rectangles and circles, respectively. Hatched rectangles and solid circles denote sites of protein contact.