Table 1.

Summary of crystallographic analysis

	Native1	Native2	I-dU5	I-dU13	I-dU24	I-dU25
Resolution, Å	2.5	3.0	2.8	3.0	3.0	3.0
Reflections, observations/unique	64,023/12,347	99,488/7,275	89,523/8,962	65,181/7,208	66,596/7,287	62,038/7,237
Data coverage, %	93.6	93.4	97.0	95.4	80.8	88.4
Rsym, %	8.0	7.5	6.7	8.7	9.6	6.6
Mean fractional isomorphous difference, %			13.7	18.9	10.0	18.6
MIR analysis, 20.0–3.0 Å against Native2
Phasing power			1.27	0.69	0.83	0.86
Rc			0.61	0.69	0.68	0.69
Mean overall figure of merit	0.62
Refinement (against Native1)
Resolution, Å	6.0–2.5
R factor/free R factor, %	21.2/33.0
Reflections, |F| > 2.0σ|F| working/test	9,726/1,121
Total no. of atoms	1,809
No. of water molecules	86
rms bond length, Å	0.016
rms bond angle, degrees	2.07
rms B-factor bonded atoms, Å2	2.29

rms, Root mean square.