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gdf6a is genetically downstream of pbx2/4 and is necessary for expression of genes in the dorsal/temporal retina. Expression of gdf6a is strongly reduced in pbx2/4 null embryos (B), when compared with wildtype (A) at 24 hpf. Knockdown of gdf6a results in a loss of aldh1a2 and tbx5 expression (D and F) when compared with wildtype (C and E). pbx2/4 null embryos were also hybridized with egr2b as well as gdf6a, as a marker of pbx function.
