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Amino acid and ATP recognition by TyrRSs. The bound substrate analogs are shown as stick models (cyan). Possible hydrogen bonds are indicated by dashed lines. Two consensus motifs, HIGH and KMSKS, conserved among the class I aaRSs are shown in blue and red, respectively. (A) Eukaryotic TyrRS (SceTyrRS). (B) Archaeal TyrRS (MjaTyrRS). (C) Bacterial TyrRS (TthTyrRS).
