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This figure shows a schematic diagram of different splicing systems in which SR proteins have been observed to behave as inhibitors of exon inclusion. (A) Shows the CE9 element characterized in the hnRNP A1 gene, (B) to the ISE element observed downstream of b-tropomyosin exon 6A, (C) to the 3RE element present in Adenovirus and (D) to the NRS element present in Rous Sarcoma Virus. Finally, a working model of the way SR proteins may inhibit CFTR exon 9 recognition is reported in (E).
