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Differential activities of furamidine, berenil and pentamidine against Tdp1. (A) Chemical structures of furamidine, berenil and pentamidine. Dashed lines indicate the variable chemical moiety. (B) Reactions were performed with the indicated concentrations (µM) of furamidine, berenil and pentamidine. Reactions were for 20 min at pH 8.0 and 25°C in the presence of 25 nM 14Y substrate and 1 ng of Tdp1. Samples were separated on a 20% urea–PAGE gel and visualized.
