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A model for Clb/Cdc28 kinase inhibition of rereplication. In G1 phase when Clb/Cdc28 is absent, Cdc6 and Mcm proteins join ORC to form the pre-RC at origins. Activation of Clb/Cdc28 kinase activity late in G1 triggers replication initiation and disassembly of the pre-RCs. The continual presence of Clb/Cdc28 during S, G2, and M phases also blocks reassembly of the pre-RC, preventing reinitiation until the Clbs are destroyed at the end of mitosis.
