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1D simulation of Ptc concentration on application of a bead containing 100 nM (a) and 10 nM (b) Shh with a Shh diffusivity corresponding to N-Shhp. Note the similarity of a to the bead-implant simulation (Fig. 3a) and the similarity of b to the tissue-implant simulation (Fig. 3b). Contours range from 0.1 to 0.5 nM (a) and 0.05 to 0.5 nM (b).
