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Plasmids to monitor mutator activity. The VDJ exon encoding the V region is functionally rearranged but no μ chain is expressed because of a TAG termination codon within the D segment. The 3′ κ enhancer is added to the minimal μ gene, and the Ig promoter has been replaced by the tk promoter. tk, tk promoter; VDJ2, V region segment; HLI, large intron enhancer, Cμ, constant region exons; 3′K, 3′ κ enhancer.
