Fig. 1.

Body weight of WT and Acc2^-/- mutant (mt) mice fed a high-fat/high-carbohydrate diet. (A) Seven- to 8-week-old male and female mice (n = 9) were fed a special diet (32% of calories from fat and 38% from carbohydrate) for 24 weeks. The weight of each mouse within each group was measured weekly; the average and variance of the weights are shown. (B) Quantification of total body weight and fat and lean components in live mice in A using the dual-energy x-ray absorptiometry methods as described in Materials and Methods. Filled bars represent mutant and empty bars represent WT. *, P < 0.05, WT vs. mutant.