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Body weight of WT and Acc2-/- mutant mice fed a high-fat diet. (A) Male mice of ≈30-g average weight (n = 3) were fed normal chow for 6 months before they were moved to a high-fat (HF) diet. After 3 months on this diet, mouse weight was measured. (B) Analysis of the fat, lean, and water (fluid) content of these mice by using the EchoMRI. The total body weight was measured for each mouse before the analysis (average weight was 35 and 43 g for mutant and WT, respectively). *, P < 0.05.
