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Differential functional profiles of TGF-β target genes. Distribution (fraction of genes) of IEGs (black bars), IRGs (gray bars), and IIGs (white bars) in “molecular function” (a) and “biological process” (b) categories as defined by the Gene Ontology Consortium (14). (c) Hierarchical model of gene regulation after ligand-induced activation of the TGF-β receptor complex (TβRI/II) (see Conclusions for details).
