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. 2003 Aug 18;100(18):10376–10381. doi: 10.1073/pnas.1834450100

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Fig. 2. — Life table analysis of insulin knockout (KO) mice. Filled squares (▪) indicate insulin homozygous KO (-/-), filled triangles (▴) indicate heterozygous KO (+/-), and filled circles (•) indicate wild-type insulin genes (+/+). (Upper) Progression to diabetes in insulin 2 KO mice is shown (A: female mice -/-, n = 13; +/-, n = 43; +/+, n = 19; B: male mice -/-, n = 13; +/-, n = 25; +/+, n = 24). (Lower) Progression to diabetes in insulin 1 KO mice is shown (C: female mice, -/-, n = 18; +/-, n = 37; +/+, n = 17; D: male mice -/-, n = 19; +/-, n = 51; +/+, n = 30). Statistical analysis was performed with prism logrank software. The three curves are dramatically different for female insulin 2 (A, P < 0.0001) and insulin 1 KO (D, P < 0.001). For male mice, insulin 1 KO mice differ significantly in progression to diabetes (C, P < 0.01).