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Peak IAA of different genotypes (-/-, +/-, +/+) of insulin knockout mice. Peak IAA index between 8 and 32 weeks of age is plotted. Statistical analysis was performed with Mann-Whitney U test. Heterozygous and homozygous knockouts versus wild type are significantly different for insulin 2 female (P < 0.05) and male (P < 0.01) mice but not for insulin 1 female and male mice.
