Figure 1.

(A) Alignment of the predicted amino acid sequences of mouse OG12a and -b and human SHOXa and -b with human SHOTa and -b. The homeodomain is shaded in dark gray. The 14-amino acid domain in the C terminus (OAR-domain) (28) is shaded in light gray. Letters in red indicate amino acid changes compared with SHOT. Letters in green indicate potential phosphorylation sites. (B) Nucleotide sequence comparison between SHOTa and SHOXa and SHOTa and OG-12a, respectively. “Homeo” indicates the homeobox region and untranslated region the 3′ untranslated regions.