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Rescue of mitochondrial membrane potential. Ian4-/- BBDP T cells were incubated for 17 h without or with anti-CD3 plus anti-CD28 mAbs (a) or for 30 min without or with cyclosporin A (CSA) (b). Gates used to identify the percentage of cells with high Δψm are indicated by horizontal bars. Data are representative of three independent experiments. Both activation and cyclosporin A rescued Ian4-/- lymphocytes from loss of Δψm.
